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SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 10 Reviews
8.8
Supplement Facts
Serving Size: Two (2) softgels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Total Carbohydrate
<1 g
<1%**
Vitamin C (as ascorbic acid)
120 mg
133%
Pacran® Whole Fruit Cranberry (Vaccinium macrocarpon)
500 mg
†
Top Medical Research Studies
9
Cranberry extracts display antifungal potential
Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans.
Strong isolated antifungal effects found
We explored how extracts from cranberry (Vaccinium macrocarpon) can affect human fungal pathogens, particularly yeast infections. Our focus was on specific strains like Candida glabrata, Candida lusitaniae, and Candida krusei, along with Cryptococcus neoformans, the latter being notorious for causing fungal meningitis.
In our testing, we found that proanthocyanidin fractions from whole cranberry fruit showed significant antifungal properties. Through a broth microdilution assay, these extracts inhibited the growth of the targeted fungi, with minimum inhibitory concentrations starting as low as 1 μg/mL.
Further analysis revealed that larger oligomers of epicatechin, detected through MALDI-TOF MS, had the strongest inhibitory effects. This research supports the idea that cranberry could be a potential natural antifungal agent, adding a new dimension to its previously known benefits against bacterial infections.
In our testing, we found that proanthocyanidin fractions from whole cranberry fruit showed significant antifungal properties. Through a broth microdilution assay, these extracts inhibited the growth of the targeted fungi, with minimum inhibitory concentrations starting as low as 1 μg/mL.
Further analysis revealed that larger oligomers of epicatechin, detected through MALDI-TOF MS, had the strongest inhibitory effects. This research supports the idea that cranberry could be a potential natural antifungal agent, adding a new dimension to its previously known benefits against bacterial infections.
Read More
8
Cranberry extracts fight yeast infections
Promising results of cranberry in the prevention of oral Candida biofilms.
Key findings on yeast treatment
We explored the antifungal properties of cranberry fruit extracts, particularly focusing on how they affect yeast infections caused by Candida species. Our study assessed both cranberry extracts and those from two other red fruits against Candida albicans and Candida glabrata.
Initial results indicated that when we added cranberry extracts to yeast cultures, they significantly reduced the ability of the fungi to adhere to surfaces, especially at low concentrations. We found that pretreating surfaces with these extracts helped combat C. glabrata more effectively and specifically showed antibiofilm activity against C. albicans.
The effectiveness of these extracts varied based on the concentration used and the specific type of yeast. Through additional phytochemical analyses of cranberry juice, we identified certain proanthocyanidin-rich subfractions that demonstrated consistent anti-adhesion properties. This study marks a significant first step in highlighting the potential benefits of using cranberry extracts as natural agents in preventing yeast biofilms, suggesting that incorporating cranberries into our diet might offer a promising strategy for dental health and antifungal protection.
Initial results indicated that when we added cranberry extracts to yeast cultures, they significantly reduced the ability of the fungi to adhere to surfaces, especially at low concentrations. We found that pretreating surfaces with these extracts helped combat C. glabrata more effectively and specifically showed antibiofilm activity against C. albicans.
The effectiveness of these extracts varied based on the concentration used and the specific type of yeast. Through additional phytochemical analyses of cranberry juice, we identified certain proanthocyanidin-rich subfractions that demonstrated consistent anti-adhesion properties. This study marks a significant first step in highlighting the potential benefits of using cranberry extracts as natural agents in preventing yeast biofilms, suggesting that incorporating cranberries into our diet might offer a promising strategy for dental health and antifungal protection.
Read More
7
Cranberry compounds aid against yeast
Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells.
Study shows potential therapeutic benefits
We explored the effects of A-type cranberry proanthocyanidins (AC-PACs) from Vaccinium macrocarpon on the yeast infection caused by Candida albicans. Through carefully designed microplate dilution assays, we evaluated how these compounds influenced both the growth of the yeast and its ability to form biofilms, which are protective barriers that allow the yeast to thrive.
While we found that AC-PACs did not significantly impact the growth of Candida albicans, they did show remarkable effects on preventing biofilm formation. Additionally, we observed that these cranberry compounds reduced the adhesion of the yeast to oral epithelial cells and acrylic resin surfaces. This suggests that AC-PACs may help combat infection by making it harder for the yeast to stick and establish itself.
In our immunological assays, we noticed an anti-inflammatory effect from the AC-PACs as well. These compounds significantly decreased the secretion of key cytokines like IL-6 and IL-8 in oral epithelial cells stimulated by the yeast. This reduction was linked to lower activation of NF-κB p65, a major player in the inflammatory response, indicating that AC-PACs may help control the inflammation associated with yeast infections.
Overall, our findings suggest that A-type cranberry proanthocyanidins can play a valuable role in preventing and treating oral candidiasis, representing a potential novel approach in managing this common fungal disease.
While we found that AC-PACs did not significantly impact the growth of Candida albicans, they did show remarkable effects on preventing biofilm formation. Additionally, we observed that these cranberry compounds reduced the adhesion of the yeast to oral epithelial cells and acrylic resin surfaces. This suggests that AC-PACs may help combat infection by making it harder for the yeast to stick and establish itself.
In our immunological assays, we noticed an anti-inflammatory effect from the AC-PACs as well. These compounds significantly decreased the secretion of key cytokines like IL-6 and IL-8 in oral epithelial cells stimulated by the yeast. This reduction was linked to lower activation of NF-κB p65, a major player in the inflammatory response, indicating that AC-PACs may help control the inflammation associated with yeast infections.
Overall, our findings suggest that A-type cranberry proanthocyanidins can play a valuable role in preventing and treating oral candidiasis, representing a potential novel approach in managing this common fungal disease.
Read More
Most Useful Reviews
9.5
Effective treatment.
It does work. I have been suffering from bladder infections, UTIs, and yeast infections for over a year. After numerous prescriptions for pain and antibiotics, I was sceptical about the cranberry pills but decided to try them as the price was reasonable. Initially, I didn't notice much change, but after two weeks, I felt the full effect. No more frequent urges to urinate, pain while peeing, or pressure in my lower stomach. My urine no longer looks cloudy or smells awful. If you're considering this, go for it; I've saved money on doctor visits and prescriptions.
Read More
7
Cleans urinary tract
This product is useful for girls dealing with yeast infections or those who feel discomfort in their sensitive areas, as it helps eliminate bacteria and unpleasant odours. Take infections seriously; I hope my comment aids you.
Read More
9.5
Excellent composition
This product has proven excellent for my yeast infections. The quality of the ingredients and packaging are superb, and it has eased my urinary burning. As it is composed of berries, the taste is pleasant and it removes the need for antibiotics.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
9
Vitamin C enhances antifungal treatment
Ascorbic Acid Enhances the Inhibitory Effect of Theasaponins against .
Limited effect of vitamin C noted
We explored the potential of vitamin C in combination with theasaponins to combat yeast infections, specifically focusing on their collective effectiveness. In this study, we used a method designed to test various concentrations of vitamin C along with theasaponins, aiming to assess how these components work together against the yeast that causes infections.
The results were telling; vitamin C significantly enhanced the ability of theasaponins to target both the yeast's active cells and its biofilm formations, which are crucial for survival. With added vitamin C, we noted a remarkable decrease in the minimum amount of theasaponins needed to inhibit growth, indicating that the combination is more potent together than alone.
Interestingly, this collaboration seemed to struggle against the yeast's communication and defense mechanisms, creating more oxidative stress and damage to cellular structures. By analyzing gene activity, we observed that the combination of vitamin C and theasaponins disrupted essential metabolic pathways, suggesting a powerful effect against the yeast.
Overall, our findings support the idea that vitamin C can play a critical role in enhancing treatments for yeast infections, showcasing its potential as part of an effective topical antifungal approach.
The results were telling; vitamin C significantly enhanced the ability of theasaponins to target both the yeast's active cells and its biofilm formations, which are crucial for survival. With added vitamin C, we noted a remarkable decrease in the minimum amount of theasaponins needed to inhibit growth, indicating that the combination is more potent together than alone.
Interestingly, this collaboration seemed to struggle against the yeast's communication and defense mechanisms, creating more oxidative stress and damage to cellular structures. By analyzing gene activity, we observed that the combination of vitamin C and theasaponins disrupted essential metabolic pathways, suggesting a powerful effect against the yeast.
Overall, our findings support the idea that vitamin C can play a critical role in enhancing treatments for yeast infections, showcasing its potential as part of an effective topical antifungal approach.
Read More
9
Vitamin C enhances antifungal safety
Effects of ascorbic acid and α-tocopherol on the therapeutic index of amphotericin B.
Focus on vitamin C effects
We investigated the effectiveness of combining vitamin C (ascorbic acid) with amphotericin B, a common antifungal medication, against the yeast Candida albicans. Our goal was to see if this combination could enhance the treatment's efficacy while reducing side effects.
Throughout our exploration, we noticed a significant boost in effectiveness when vitamin C was included, with improvements ranging from 7% to 12% compared to using amphotericin B by itself. This enhancement could be attributed to vitamin C’s antioxidant properties, which seem to help protect red blood cells from amphotericin B’s potentially harmful effects.
However, despite these promising findings, we also observed that the yeast returned after 24 hours, regardless of whether vitamin C or vitamin E was included in the treatment. This suggests that while antioxidants appear to improve the safety profile of the antifungal agent, they do not entirely eliminate the yeast.
Overall, our study indicates that incorporating vitamin C into antifungal treatments holds promise for improving their therapeutic index, offering better safety with the potential for enhanced effectiveness against yeast infections.
Throughout our exploration, we noticed a significant boost in effectiveness when vitamin C was included, with improvements ranging from 7% to 12% compared to using amphotericin B by itself. This enhancement could be attributed to vitamin C’s antioxidant properties, which seem to help protect red blood cells from amphotericin B’s potentially harmful effects.
However, despite these promising findings, we also observed that the yeast returned after 24 hours, regardless of whether vitamin C or vitamin E was included in the treatment. This suggests that while antioxidants appear to improve the safety profile of the antifungal agent, they do not entirely eliminate the yeast.
Overall, our study indicates that incorporating vitamin C into antifungal treatments holds promise for improving their therapeutic index, offering better safety with the potential for enhanced effectiveness against yeast infections.
Read More
9
Cranberry extracts display antifungal potential
Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans.
Strong isolated antifungal effects found
We explored how extracts from cranberry (Vaccinium macrocarpon) can affect human fungal pathogens, particularly yeast infections. Our focus was on specific strains like Candida glabrata, Candida lusitaniae, and Candida krusei, along with Cryptococcus neoformans, the latter being notorious for causing fungal meningitis.
In our testing, we found that proanthocyanidin fractions from whole cranberry fruit showed significant antifungal properties. Through a broth microdilution assay, these extracts inhibited the growth of the targeted fungi, with minimum inhibitory concentrations starting as low as 1 μg/mL.
Further analysis revealed that larger oligomers of epicatechin, detected through MALDI-TOF MS, had the strongest inhibitory effects. This research supports the idea that cranberry could be a potential natural antifungal agent, adding a new dimension to its previously known benefits against bacterial infections.
In our testing, we found that proanthocyanidin fractions from whole cranberry fruit showed significant antifungal properties. Through a broth microdilution assay, these extracts inhibited the growth of the targeted fungi, with minimum inhibitory concentrations starting as low as 1 μg/mL.
Further analysis revealed that larger oligomers of epicatechin, detected through MALDI-TOF MS, had the strongest inhibitory effects. This research supports the idea that cranberry could be a potential natural antifungal agent, adding a new dimension to its previously known benefits against bacterial infections.
Read More
8
Cranberry extracts fight yeast infections
Promising results of cranberry in the prevention of oral Candida biofilms.
Key findings on yeast treatment
We explored the antifungal properties of cranberry fruit extracts, particularly focusing on how they affect yeast infections caused by Candida species. Our study assessed both cranberry extracts and those from two other red fruits against Candida albicans and Candida glabrata.
Initial results indicated that when we added cranberry extracts to yeast cultures, they significantly reduced the ability of the fungi to adhere to surfaces, especially at low concentrations. We found that pretreating surfaces with these extracts helped combat C. glabrata more effectively and specifically showed antibiofilm activity against C. albicans.
The effectiveness of these extracts varied based on the concentration used and the specific type of yeast. Through additional phytochemical analyses of cranberry juice, we identified certain proanthocyanidin-rich subfractions that demonstrated consistent anti-adhesion properties. This study marks a significant first step in highlighting the potential benefits of using cranberry extracts as natural agents in preventing yeast biofilms, suggesting that incorporating cranberries into our diet might offer a promising strategy for dental health and antifungal protection.
Initial results indicated that when we added cranberry extracts to yeast cultures, they significantly reduced the ability of the fungi to adhere to surfaces, especially at low concentrations. We found that pretreating surfaces with these extracts helped combat C. glabrata more effectively and specifically showed antibiofilm activity against C. albicans.
The effectiveness of these extracts varied based on the concentration used and the specific type of yeast. Through additional phytochemical analyses of cranberry juice, we identified certain proanthocyanidin-rich subfractions that demonstrated consistent anti-adhesion properties. This study marks a significant first step in highlighting the potential benefits of using cranberry extracts as natural agents in preventing yeast biofilms, suggesting that incorporating cranberries into our diet might offer a promising strategy for dental health and antifungal protection.
Read More
7
Cranberry compounds aid against yeast
Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells.
Study shows potential therapeutic benefits
We explored the effects of A-type cranberry proanthocyanidins (AC-PACs) from Vaccinium macrocarpon on the yeast infection caused by Candida albicans. Through carefully designed microplate dilution assays, we evaluated how these compounds influenced both the growth of the yeast and its ability to form biofilms, which are protective barriers that allow the yeast to thrive.
While we found that AC-PACs did not significantly impact the growth of Candida albicans, they did show remarkable effects on preventing biofilm formation. Additionally, we observed that these cranberry compounds reduced the adhesion of the yeast to oral epithelial cells and acrylic resin surfaces. This suggests that AC-PACs may help combat infection by making it harder for the yeast to stick and establish itself.
In our immunological assays, we noticed an anti-inflammatory effect from the AC-PACs as well. These compounds significantly decreased the secretion of key cytokines like IL-6 and IL-8 in oral epithelial cells stimulated by the yeast. This reduction was linked to lower activation of NF-κB p65, a major player in the inflammatory response, indicating that AC-PACs may help control the inflammation associated with yeast infections.
Overall, our findings suggest that A-type cranberry proanthocyanidins can play a valuable role in preventing and treating oral candidiasis, representing a potential novel approach in managing this common fungal disease.
While we found that AC-PACs did not significantly impact the growth of Candida albicans, they did show remarkable effects on preventing biofilm formation. Additionally, we observed that these cranberry compounds reduced the adhesion of the yeast to oral epithelial cells and acrylic resin surfaces. This suggests that AC-PACs may help combat infection by making it harder for the yeast to stick and establish itself.
In our immunological assays, we noticed an anti-inflammatory effect from the AC-PACs as well. These compounds significantly decreased the secretion of key cytokines like IL-6 and IL-8 in oral epithelial cells stimulated by the yeast. This reduction was linked to lower activation of NF-κB p65, a major player in the inflammatory response, indicating that AC-PACs may help control the inflammation associated with yeast infections.
Overall, our findings suggest that A-type cranberry proanthocyanidins can play a valuable role in preventing and treating oral candidiasis, representing a potential novel approach in managing this common fungal disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.8
9.5
Relieved infections
It effectively relieves my yeast infections, protects against them, and helps eliminate unwanted odours.
9.5
Excellent composition
This product has proven excellent for my yeast infections. The quality of the ingredients and packaging are superb, and it has eased my urinary burning. As it is composed of berries, the taste is pleasant and it removes the need for antibiotics.
9.5
Effective treatment.
It does work. I have been suffering from bladder infections, UTIs, and yeast infections for over a year. After numerous prescriptions for pain and antibiotics, I was sceptical about the cranberry pills but decided to try them as the price was reasonable. Initially, I didn't notice much change, but after two weeks, I felt the full effect. No more frequent urges to urinate, pain while peeing, or pressure in my lower stomach. My urine no longer looks cloudy or smells awful. If you're considering this, go for it; I've saved money on doctor visits and prescriptions.
Read More
8.8
Effective treatment
I have tried many brands, but this one is the best so far. I used to take D mannose, but I stopped to see if this product alone would suffice. It worked! I now take two softgels daily as recommended, and it has been effective against yeast infections.
8.8
Reduced infections
After trying this product for the second time, it significantly reduced my yeast infections.
